Leading article Helicobacter pylori induced apoptosis
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چکیده
Apoptosis, like Helicobacter pylori, has a long history, extending back into the 19th Century. Apoptosis was ignored or forgotten, just like H pylori, only to reemerge relatively recently. However, with the current exponential increase in the number of publications concerning H pylori, and in those written about apoptosis, it was only a matter of time before the influence of H pylori on apoptosis was investigated. We shall review the recent evidence that indicates that H pylori is capable of inducing apoptosis in gastric epithelial cells, and explore the mechanisms and major implication of this finding—that an alteration of gastric epithelial apoptosis may relate to the outcome of chronic H pylori colonisation.
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Leading article Helicobacter pylori induced apoptosis
Apoptosis, like Helicobacter pylori, has a long history, extending back into the 19th Century. Apoptosis was ignored or forgotten, just like H pylori, only to reemerge relatively recently. However, with the current exponential increase in the number of publications concerning H pylori, and in those written about apoptosis, it was only a matter of time before the influence of H pylori on apoptos...
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The enhanced gastric epithelial cell apoptosis observed during infection with Helicobacter pylori has been suggested to be of significance in the etiology of gastritis, peptic ulcers, and neoplasia. To investigate the cell death signaling induced by H. pylori infection, human gastric epithelial cells were incubated with H. pylori for up to 72 h. H. pylori infection induced the activation of cas...
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Helicobacter pylori infection is associated with gastric epithelial damage, including apoptosis, ulceration, and cancer. Although bacterial factors and the host response are believed to contribute to gastric disease, no receptor has been identified that explains how the bacteria attach and signal the host cell to undergo apoptosis. Using H. pylori as "bait" to capture receptor proteins in solub...
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